Pancreatic polypeptide: a possible role in the regulation of food intake in the mouse. Hypothesis.

Experientia ·Vol. 33 ·No. 7 ·1977-07-15 ·Pages 915-7

Malaisse-Lagae F, Carpentier JL, Patel YC, Malaisse WJ, Orci L

Abstract

Pancreatic polypeptide (PP) is a recently identified hormone produced by pancreatic endocrine cells. The islets of genetically obese mice (ob/ob, C57 BL/6J), which are suspected to lack a circulating satiety factor, contain relatively few of the PP-producing cells. Administration of bovine pancreatic polypeptide (bPP) reduces food intake and suppresses body weight gain in the hyperphagic obese mice. It is postulated that PP participates in the regulation of food intake in a manner as yet undefined.

MeSH Terms

Animals Body Weight Eating/drug effects Hormones/pharmacology,physiology Mice Mice, Obese Obesity/physiopathology Pancreas/physiology,physiopathology Peptides/pharmacology,physiology

Chemicals

Hormones Peptides

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Malaisse-Lagae F

Carpentier J L

Patel Y C

Malaisse W J

Orci L

References (15)

15 references, click to expand

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Pancreatic polypeptide - a postulated new hormone: identification of its cellular storage site by light and electron microscopic immunocytochemistry.
Diabetologia. 1976 Jul;12(3):211-26 PMID: 782992
Effects of parabiosis of obese with diabetes and normal mice.
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Pancreatic polypeptide in insulinomas, gastrinomas, vipomas, and glucagonomas.
Lancet. 1976 Feb 14;1(7955):328-30 PMID: 54738
Candidate hormones of the gut. VI. Bovine pancreatic polypeptide (BPP) and avian pancreatic polypeptide (APP).
Gastroenterology. 1974 Oct;67(4):737-8 PMID: 4606297
The influence of genetic background on the expression of the obese (Ob) gene in the mouse.
Diabetologia. 1973 Aug;9(4):287-93 PMID: 4588246
Studies of the distribution of a new avian pancreatic polypeptide and insulin among birds, reptiles, amphibians and mammals.
Endocrinology. 1973 Sep;93(3):558-65 PMID: 4198471
Distribution and release of human pancreatic polypeptide.
Gut. 1976 Dec;17(12):940-44 PMID: 828120
Mechanism of pancreatic polypeptide release in man.
Lancet. 1977 Jan 22;1(8004):161-3 PMID: 64696
Spectrum effects of a new polypeptide (third hormone?) isolated from the chicken pancreas.
Gen Comp Endocrinol. 1973 Dec;21(3):485-97 PMID: 4587115
Localization of bovine pancreatic polypeptide (BPP)-like immunoreactivity in rat pancreatic monolayer culture.
Experientia. 1976;32(7):919-20 PMID: 60252
[Pancreatic polypeptide islets and glucagon islets : distinct topographic distribution in rat pancreas].
C R Acad Sci Hebd Seances Acad Sci D. 1976 Oct 27;283(10):1213-6 PMID: 827358
Diurnal variations of food consumption, plasma glucose and plasma insulin concentrations in lean and obese hyperglycaemic mice.
Horm Res. 1975;6(5-6):380-6 PMID: 1241779
Isolation and characterization of chicken insulin.
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Localization of APP, a postulated new hormone, to a pancreatic endocrine cell type.
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Article Info

Journal

Experientia

Abbr.

Experientia

ISSN

0014-4754

DOI

10.1007/BF01951279

Published

1977-07-15

Pages

915-7

Language

English

Region

Switzerland

NLM ID

0376547

Subset

External Links

PubMed source DOI: 10.1007/BF01951279

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Pancreatic polypeptide: a possible role in the regulation of food intake in the mouse. Hypothesis.

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