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PMID: 8890246 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Role of neutrophils in controlling early stages of a Chlamydia trachomatis infection.

Infection and immunity ·Vol. 64 ·No. 11 ·1996-11-00 ·Pages 4830-3

Barteneva N, Theodor I, Peterson EM, de la Maza LM

Abstract

Inoculation of mice with the granulocyte-depleting monoclonal antibody RB6-8C5 showed that neutrophils are critical protective effector cells during a Chlamydia trachomatis infection. In addition, administration of monoclonal antibody 2E6 demonstrated that extravasation of neutrophils into the peritoneal cavity in response to inoculation with the C. trachomatis MoPn biovar is dependent on the surface beta-2 integrin molecule CD18.

MeSH Terms
Animals CD18 Antigens/immunology Chlamydia Infections/immunology Chlamydia trachomatis/immunology Eosinophils/immunology Female Mice Mice, Inbred BALB C Neutrophils/immunology
Chemicals
CD18 Antigens
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Barteneva N
Department of Pathology, University of California, Irvine 92697-4800, USA.
Theodor I
Peterson E M
de la Maza L M
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.64.11.4830-4833.1996
Published
1996-11-00
Pages
4830-3
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC174452
Subset
IM
Grants
NIAID NIH HHS · AI-30499 · United States
NIAID NIH HHS · AI-32248 · United States
External Links
PubMed source DOI: 10.1128/iai.64.11.4830-4833.1996 PMC Full Text View journal details
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