Abstract
Tumor necrosis factor receptor-1 (TNFR-1) and CD95 (also called Fas or APO-1) are cytokine receptors that engage the apoptosis pathway through a region of intracellular homology, designated the "death domain." Another death domain-containing member of the TNFR family, death receptor 3 (DR3), was identified and was shown to induce both apoptosis and activation of nuclear factor kappaB. Expression of DR3 appears to be restricted to tissues enriched in lymphocytes. DR3 signal transduction is mediated by a complex of intracellular signaling molecules including TRADD, TRAF2, FADD, and FLICE. Thus, DR3 likely plays a role in regulating lymphocyte homeostasis.
MeSH Terms
Adaptor Proteins, Signal Transducing
Amino Acid Sequence
Apoptosis
Carrier Proteins/metabolism
Caspase 8
Caspase 9
Caspases
Cloning, Molecular
Cysteine Endopeptidases/metabolism
Fas-Associated Death Domain Protein
Gene Library
Humans
Lymphocytes
Molecular Sequence Data
NF-kappa B/physiology
Organ Specificity
Proteins/metabolism
RNA, Messenger/analysis,genetics
Receptors, Tumor Necrosis Factor/chemistry,genetics,physiology
Receptors, Tumor Necrosis Factor, Member 25
Sequence Alignment
Signal Transduction
TNF Receptor-Associated Factor 1
TNF Receptor-Associated Factor 2
Transfection
Tumor Cells, Cultured
fas Receptor/chemistry,physiology
Chemicals
Adaptor Proteins, Signal Transducing
Carrier Proteins
FADD protein, human
Fas-Associated Death Domain Protein
NF-kappa B
Proteins
RNA, Messenger
Receptors, Tumor Necrosis Factor
Receptors, Tumor Necrosis Factor, Member 25
TNF Receptor-Associated Factor 1
TNF Receptor-Associated Factor 2
TNFRSF25 protein, human
fas Receptor
CASP8 protein, human
CASP9 protein, human
Caspase 8
Caspase 9
Caspases
Cysteine Endopeptidases
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Chinnaiyan A M
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Sciences Inc., 9620 Medical Center Driv.
O'Rourke K
Yu G L
Lyons R H
Garg M
Duan D R
Xing L
Gentz R
Ni J
Dixit V M