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PMID: 8875942 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95.

Science (New York, N.Y.) ·Vol. 274 ·No. 5289 ·1996-11-08 ·Pages 990-2

Chinnaiyan AM, O'Rourke K, Yu GL, Lyons RH, Garg M, Duan DR, Xing L, Gentz R, Ni J, Dixit VM

Abstract

Tumor necrosis factor receptor-1 (TNFR-1) and CD95 (also called Fas or APO-1) are cytokine receptors that engage the apoptosis pathway through a region of intracellular homology, designated the "death domain." Another death domain-containing member of the TNFR family, death receptor 3 (DR3), was identified and was shown to induce both apoptosis and activation of nuclear factor kappaB. Expression of DR3 appears to be restricted to tissues enriched in lymphocytes. DR3 signal transduction is mediated by a complex of intracellular signaling molecules including TRADD, TRAF2, FADD, and FLICE. Thus, DR3 likely plays a role in regulating lymphocyte homeostasis.

MeSH Terms
Adaptor Proteins, Signal Transducing Amino Acid Sequence Apoptosis Carrier Proteins/metabolism Caspase 8 Caspase 9 Caspases Cloning, Molecular Cysteine Endopeptidases/metabolism Fas-Associated Death Domain Protein Gene Library Humans Lymphocytes Molecular Sequence Data NF-kappa B/physiology Organ Specificity Proteins/metabolism RNA, Messenger/analysis,genetics Receptors, Tumor Necrosis Factor/chemistry,genetics,physiology Receptors, Tumor Necrosis Factor, Member 25 Sequence Alignment Signal Transduction TNF Receptor-Associated Factor 1 TNF Receptor-Associated Factor 2 Transfection Tumor Cells, Cultured fas Receptor/chemistry,physiology
Chemicals
Adaptor Proteins, Signal Transducing Carrier Proteins FADD protein, human Fas-Associated Death Domain Protein NF-kappa B Proteins RNA, Messenger Receptors, Tumor Necrosis Factor Receptors, Tumor Necrosis Factor, Member 25 TNF Receptor-Associated Factor 1 TNF Receptor-Associated Factor 2 TNFRSF25 protein, human fas Receptor CASP8 protein, human CASP9 protein, human Caspase 8 Caspase 9 Caspases Cysteine Endopeptidases
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Chinnaiyan A M
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Sciences Inc., 9620 Medical Center Driv.
O'Rourke K
Yu G L
Lyons R H
Garg M
Duan D R
Xing L
Gentz R
Ni J
Dixit V M
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
Published
1996-11-08
Pages
990-2
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NIGMS NIH HHS · GM-07863 · United States
Databases
GENBANK
U72763
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