Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles.

Antimicrobial agents and chemotherapy ·Vol. 40 ·No. 4 ·1996-04-00 ·Pages 1020-3

Deguchi T, Yasuda M, Nakano M, Ozeki S, Ezaki T, Saito I, Kawada Y

Abstract

Fifty-five clinical strains of Neisseria gonorrhoeae were examined for mutations in the gyrA and parC genes and for antimicrobial susceptibility profiles. The MICs of quinolones for 31 strains with alterations in GyrA were significantly higher than the MICs for 24 strains without such alterations. Eleven strains with alterations in both GyrA and ParC were significantly more resistant to fluoroquinolones than those with alterations in GyrA alone. The MICs of cephalosporins for these strains were also significantly higher than those for other strains.

MeSH Terms

Amino Acid Sequence Anti-Bacterial Agents/pharmacology Anti-Infective Agents/pharmacology Base Sequence DNA Gyrase DNA Topoisomerase IV DNA Topoisomerases, Type II/genetics Drug Resistance, Microbial/genetics Fluoroquinolones Microbial Sensitivity Tests Molecular Sequence Data Neisseria gonorrhoeae/drug effects,genetics Sequence Homology

Chemicals

Anti-Bacterial Agents Anti-Infective Agents Fluoroquinolones DNA Topoisomerase IV DNA Gyrase DNA Topoisomerases, Type II

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Deguchi T

Department of Urology, Gifu University School of Medicine, Japan.

Yasuda M

Nakano M

Ozeki S

Ezaki T

Saito I

Kawada Y

References (9)

9 references, click to expand

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Characterization of a gyrB mutation responsible for low-level nalidixic acid resistance in Neisseria gonorrhoeae.
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DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae.
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Susceptibility of Neisseria gonorrhoeae associated with pelvic inflammatory disease to cefoxitin, ceftriaxone, clindamycin, gentamicin, doxycycline, azithromycin, and other antimicrobial agents.
Antimicrob Agents Chemother. 1994 Jul;38(7):1688-91 PMID: 7979312
Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones.
Mol Microbiol. 1994 Aug;13(4):641-53 PMID: 7997176
Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates.
Mol Microbiol. 1994 Oct;14(2):371-80 PMID: 7830580
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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.40.4.1020

Published

1996-04-00

Pages

1020-3

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC163251

Subset

External Links

PubMed source DOI: 10.1128/AAC.40.4.1020 PMC Full Text View journal details

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Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles.

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