Altered beta-adrenergic receptor signaling in heart failure, in vivo gene transfer via adeno and adeno-associated virus.

Adenoviruses, Human/genetics Adenylyl Cyclases/biosynthesis,genetics,physiology Animals Cardiac Pacing, Artificial Coronary Vessels/metabolism Cyclic AMP-Dependent Protein Kinases/biosynthesis,genetics,physiology Defective Viruses/genetics Dependovirus/genetics Disease Models, Animal G-Protein-Coupled Receptor Kinase 5 GTP-Binding Protein alpha Subunits, Gs/genetics,physiology Gene Transfer Techniques Genetic Vectors/genetics Heart Failure/physiopathology,therapy Mice Muscle, Smooth, Vascular/metabolism Myocardium/metabolism Polymerase Chain Reaction Protein Serine-Threonine Kinases Receptor Protein-Tyrosine Kinases/biosynthesis,genetics,physiology Receptors, Adrenergic, beta/physiology Recombinant Fusion Proteins/biosynthesis,genetics Signal Transduction/genetics,physiology Swine beta-Adrenergic Receptor Kinases

Receptors, Adrenergic, beta Recombinant Fusion Proteins Receptor Protein-Tyrosine Kinases Protein Serine-Threonine Kinases Cyclic AMP-Dependent Protein Kinases beta-Adrenergic Receptor Kinases G-Protein-Coupled Receptor Kinase 5 GRK5 protein, human Grk5 protein, mouse GTP-Binding Protein alpha Subunits, Gs Adenylyl Cyclases