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PMID: 881194 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Karyotyping of bone-marrow cells in hematologic diseases.

Human genetics ·Vol. 37 ·No. 1 ·1977-06-10 ·Pages 33-9

Morse HG, Humbert JR, Hutter JJ, Robinson A

Abstract

Cultures of bone-marrow cells incubated for 5 h at 4 degrees had cells in metaphase with elongated chromosomes which were easily Giemsa banded. Colcemid was not necessary for metaphase arrest at this temperature. This technique made possible routine karyotyping of patients with leukemia and other hematological diseases in which the detection of aberrations was otherwise difficult.

MeSH Terms

Bone Marrow Bone Marrow Cells Child Culture Techniques Hematologic Diseases/genetics Humans Karyotyping Leukemia/genetics Mitosis

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Morse H G

Humbert J R

Hutter J J

Robinson A

References (5)

5 references, click to expand

The G-banded prophase chromosomes of man.
Humangenetik. 1975;27(3):167-72 PMID: 50274
Chromosome preparations of bone marrow cells without prior in vitro culture or in vivo colchicine administration.
Stain Technol. 1962 Jan;37:17-20 PMID: 13921436
Bone-marrow chromosomes in healthy subjects.
Hereditas. 1976;82(1):29-35 PMID: 1262236
Non-leukemic dividing cells in the blood of leukemic patients.
Am J Hematol. 1978;4(3):217-24 PMID: 281127
Identification of chromosome anomalies in the blastic phase of chronic myelocytic leukemia (CML) by Giemsa- and quinacrine-banding techniques.
Humangenetik. 1974 Jul 15;23(2):111-8 PMID: 4136793

Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00293769

Published

1977-06-10

Pages

33-9

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00293769 View journal details

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