Mutational analysis of structure-function relationship of RNA polymerase in Escherichia coli.

Aminoglycosides Anti-Bacterial Agents/metabolism,pharmacology Bacterial Proteins/antagonists & inhibitors,chemistry,genetics,physiology Binding Sites Catalysis DNA-Directed RNA Polymerases/antagonists & inhibitors,chemistry,genetics,physiology Escherichia coli/enzymology,genetics Genes, Bacterial Mutagenesis, Site-Directed Nucleic Acid Synthesis Inhibitors/metabolism,pharmacology Promoter Regions, Genetic Protein Conformation Rifampin/metabolism,pharmacology Structure-Activity Relationship Terminator Regions, Genetic Transcription, Genetic/drug effects

Aminoglycosides Anti-Bacterial Agents Bacterial Proteins Nucleic Acid Synthesis Inhibitors sorangicin A streptolydigin DNA-Directed RNA Polymerases Rifampin