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PMID: 878851 Published · ppublish English Journal Article

The pathophysiology of the blood-brain barrier dysfunction induced by severe hypercapnia and by epileptic brain activity.

Acta neuropathologica ·Vol. 38 ·No. 2 ·1977-05-16 ·Pages 153-8

Johansson B, Nilsson B

Abstract

The cerebrovascular permeability to protein was studied in hypercapnic rats and in rats with epileptic seizures induced by bicuculline and homocysteine. Despite the differences of the basic pathophysiological mechanisms involved in these models, the blood-brain barrier (BBB) dysfunction was clearly related to the combined effects of high blood pressure and cerebral vasodilatation, thus indicating mechanical factors to be predominantly involved. The BBB changes were most frequent in central and basal regions in contrast to those induced by acute hypertension, which are most common in cortical areas.

MeSH Terms
Animals Bicuculline Blood Pressure Blood-Brain Barrier Epilepsy/pathology Homocysteine Hypercapnia/pathology Hypertension Male Permeability Phentolamine Proteins Rats
Chemicals
Proteins Homocysteine Bicuculline Phentolamine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Johansson B
Nilsson B
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24 references, click to expand
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Article Info
Journal
Acta neuropathologica
Abbr.
Acta Neuropathol
ISSN
0001-6322
DOI
10.1007/BF00688563
Published
1977-05-16
Pages
153-8
Language
English
Region
Germany
NLM ID
0412041
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00688563 View journal details
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