The inositol triphosphate receptor family.

Cellular signalling ·Vol. 8 ·No. 1 ·1996-01-00 ·Pages 1-7

Joseph SK

Abstract

Specific receptors on intracellular membranes mediate the Ca2+ mobilization induced by the second messenger molecule D-myo-inositol 1,4,5-triphosphate (IP3). Most cell types appear to contain multiple receptor isoforms. The review summarizes recent progress on IP3 receptor biology with a particular emphasis on distinctive structural and regulatory features of the individual isoforms.

MeSH Terms

Animals Binding Sites Calcium/physiology Calcium Channels/chemistry,classification,genetics,physiology Cloning, Molecular Humans Inositol 1,4,5-Trisphosphate/physiology Inositol 1,4,5-Trisphosphate Receptors Ion Channel Gating Ligands Macromolecular Substances Protein Conformation Receptors, Cytoplasmic and Nuclear/chemistry,classification,genetics,physiology Second Messenger Systems/physiology

Chemicals

Calcium Channels ITPR1 protein, human Inositol 1,4,5-Trisphosphate Receptors Ligands Macromolecular Substances Receptors, Cytoplasmic and Nuclear Inositol 1,4,5-Trisphosphate Calcium

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Joseph S K

Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, PA 19107, USA. josephs@jeflin.tju.edu

Article Info

Journal

Cellular signalling

Abbr.

Cell Signal

ISSN

0898-6568

DOI

10.1016/0898-6568(95)02012-8

josephs@jeflin.tju.edu

Published

1996-01-00

Pages

1-7

Language

English

Region

England

NLM ID

8904683

Subset

External Links

PubMed source DOI: 10.1016/0898-6568(95)02012-8 View journal details

Analysis Services

The inositol triphosphate receptor family.

Contact

WeChat Official Account