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PMID: 877581 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Hepatic binding protein: the protective role of its sialic acid residues.

Science (New York, N.Y.) ·Vol. 197 ·No. 4304 ·1977-08-12 ·Pages 667-8

Stockert RJ, Morell AG, Scheinberg IH

Abstract

Removal of sialic acid from a specific hepatic binding protein virtually abolishes its capacity to bind certain asialoglycoproteins. The loss of this capacity is the result of competition for the binding sites by galactosyl residues, of hepatic binding protein, that become terminal after desialylation.

MeSH Terms
Acetylgalactosamine/metabolism Binding Sites Carrier Proteins/metabolism Glycoproteins/metabolism Liver/metabolism Membrane Proteins/metabolism Mucins/metabolism Orosomucoid/metabolism Sialic Acids/metabolism Structure-Activity Relationship
Chemicals
Carrier Proteins Glycoproteins Membrane Proteins Mucins Orosomucoid Sialic Acids Acetylgalactosamine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Stockert R J
Morell A G
Scheinberg I H
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.877581
Published
1977-08-12
Pages
667-8
Language
English
Region
United States
NLM ID
0404511
Subset
IM
External Links
PubMed source DOI: 10.1126/science.877581 View journal details
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