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PMID: 8769186 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Are cytochrome P450 3A enzymes in the small intestine responsible for different cyclosporine metabolite patterns in stable male and female renal allograft recipients after co-administration of diltiazem?

Transplantation proceedings ·Vol. 28 ·No. 4 ·1996-08-00 ·Pages 2159-61

Christians U, Bleck JS, Lampen A, Bader A, Thiesemann C, Kliem V, Repp H, Westhoff-Bleck M, Manns M, Sewing KF

Abstract

暂无摘要

MeSH Terms

Adolescent Adult Aged Calcium Channel Blockers/pharmacology Cyclosporine/metabolism,pharmacokinetics,therapeutic use Cytochrome P-450 CYP2E1 Cytochrome P-450 Enzyme System/metabolism Diltiazem/pharmacology Duodenum Female Humans Immunosuppressive Agents/metabolism,pharmacokinetics,therapeutic use Intestinal Mucosa/enzymology Kidney Transplantation/immunology Male Metabolic Clearance Rate Microsomes/enzymology Middle Aged Mixed Function Oxygenases/metabolism Sex Characteristics

Chemicals

Calcium Channel Blockers Immunosuppressive Agents Cyclosporine Cytochrome P-450 Enzyme System Mixed Function Oxygenases Cytochrome P-450 CYP2E1 Diltiazem

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Christians U

Institut für Allgemeine Pharmakologie, Medizinische Hochschule Hannover, Germany.

Bleck J S

Lampen A

Bader A

Thiesemann C

Kliem V

Repp H

Westhoff-Bleck M

Manns M

Sewing K F

Article Info

Journal

Transplantation proceedings

Abbr.

Transplant Proc

ISSN

0041-1345

Published

1996-08-00

Pages

2159-61

Language

English

Region

United States

NLM ID

0243532

Subset

External Links

PubMed source View journal details

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Are cytochrome P450 3A enzymes in the small intestine responsible for different cyclosporine metabolite patterns in stable male and female renal allograft recipients after co-administration of diltiazem?

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