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题目:: GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits.
作者:: Berman(D M),Wilkie(T M),Gilman(A G)
状态:: 发布时间1996-09-26 , 更新时间 2013-11-21
期刊:: Cell
摘要:: A novel class of regulators of G protein signaling (RGS) proteins has been identified recently. Genetic evidence suggests that RGS proteins inhibit G protein-mediated signaling at the level of the receptor-G protein interaction or the G protein alpha subunit itself. We have found that two RGS family members, GAIP and RGS4, are GTPase-activating proteins (GAPs), accelerating the rate of GTP hydrolysis by Gi alpha 1 at least 40-fold. All Gi subfamily members assayed were substrates for these GAPs; Gs alpha was not. RGS4 activates the GTPase activity of certain Gi alpha 1 mutants (e.g., R178C), but not others (e.g., Q204L). The GAP activity of RGS proteins is consistent with their proposed role as negative regulators of G protein-mediated signaling.
语言:: eng
DOI:

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