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PMID: 8752357 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Insertional inactivation of the gene for collagen-binding protein has a pleiotropic effect on the phenotype of Staphylococcus aureus.

Journal of bacteriology ·Vol. 178 ·No. 17 ·1996-09-00 ·Pages 5327-9

Hienz SA, Palma M, Flock JI

Abstract

This report describes phenotypical changes caused by the insertional inactivation of the gene for the collagen-binding protein in Staphylococcus aureus PH100. Insertional inactivation resulted in reductions in the amount of fibronectin-binding protein in PH100 and the ability of intact cells to aggregate in the presence of fibronectin. However, the capacity of PH100 to adhere to immobilized fibronectin remained the same.

MeSH Terms
Adhesins, Bacterial Bacterial Proteins/metabolism Collagen/metabolism Mutagenesis, Insertional Phenotype Staphylococcus aureus/genetics,metabolism
Chemicals
Adhesins, Bacterial Bacterial Proteins adhesin, Staphylococcus aureus Collagen
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hienz S A
Department of Immunology, Microbiology, Pathology and Infectious Diseases, Karolinska Institute, Huddinge University Hospital, Sweden.
Palma M
Flock J I
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.178.17.5327-5329.1996
Published
1996-09-00
Pages
5327-9
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC178336
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.178.17.5327-5329.1996 PMC Full Text View journal details
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