Home LiteratureArticle Details
PMID: 8718625 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Meiotic recombination break points resolve at high rates at the 5' end of a maize coding sequence.

The Plant cell ·Vol. 7 ·No. 12 ·1995-12-00 ·Pages 2151-61

Xu X, Hsia AP, Zhang L, Nikolau BJ, Schnable PS

Abstract

Sequence analysis of recombination break points has defined a 377-bp recombination hot spot within the anthocyanin 1 (a1) gene. One-fifth of all recombination events that occurred within the 140-kb a1-shrunken 2 interval resolved within this 377-bp hot spot. In yeast, meiotic double-strand breaks in chromosomal DNA are thought to initiate recombination and are generally located 5' of coding regions, near transcription promoter sequences. Because the a1 recombination hot spot is located within the 5' transcribed region of the a1 gene, the sites at which recombination events initiate and resolve appear to be different, but both appear to be regulated in relation to transcribed sequences. Although transposon insertions are known to suppress recombination and alter the ratio of crossovers to apparent gene conversions, the Mutator 1 transposon insertion in the a1-mum2 allele does not alter the sites at which recombination events resolve.

MeSH Terms
Alleles Base Sequence Crosses, Genetic DNA Primers DNA Transposable Elements Genes, Plant Introns Kinetics Meiosis Models, Genetic Molecular Sequence Data Polymerase Chain Reaction Recombination, Genetic Transcription, Genetic Zea mays/cytology,genetics
Chemicals
DNA Primers DNA Transposable Elements
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Xu X
Department of Zoology and Genetics, Iowa State University, Ames 50011, USA.
Hsia A P
Zhang L
Nikolau B J
Schnable P S
References (31)
31 references, click to expand
  1. Starch-deficient maize mutant lacking adenosine dephosphate glucose pyrophosphorylase activity.
    Science. 1966 Jan 21;151(3708):341-3 PMID: 5903344
  2. Repression of meiotic crossing over by a centromere (CEN3) in Saccharomyces cerevisiae.
    Genetics. 1986 Nov;114(3):769-89 PMID: 3539697
  3. High density molecular linkage maps of the tomato and potato genomes.
    Genetics. 1992 Dec;132(4):1141-60 PMID: 1360934
  4. Meiosis-induced double-strand break sites determined by yeast chromatin structure.
    Science. 1994 Jan 28;263(5146):515-8 PMID: 8290959
  5. A short chromosomal region with major roles in yeast chromosome III meiotic disjunction, recombination and double strand breaks.
    Genetics. 1993 Feb;133(2):159-69 PMID: 8436266
  6. Hotspots of meiotic recombination in the mouse major histocompatibility complex.
    Genetica. 1993;88(2-3):187-96 PMID: 8224858
  7. Allelic variation at the level of intragenic recombination.
    Genetics. 1978 May;89(1):211-24 PMID: 17248830
  8. Molecular cloning of the a1 locus of Zea mays using the transposable elements En and Mu1.
    EMBO J. 1985 Apr;4(4):877-82 PMID: 15938046
  9. Genetic and physical analysis of the M26 recombination hotspot of Schizosaccharomyces pombe.
    Genetics. 1988 Jul;119(3):491-7 PMID: 3402730
  10. A specific DNA sequence is required for high frequency of recombination in the ade6 gene of fission yeast.
    EMBO J. 1991 Aug;10(8):2157-63 PMID: 2065658
  11. A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae.
    Cell. 1990 Jun 15;61(6):1089-101 PMID: 2190690
  12. An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae.
    Nature. 1989 Mar 2;338(6210):35-9 PMID: 2537472
  13. The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers.
    Gene. 1982 Oct;19(3):259-68 PMID: 6295879
  14. Genetic analysis of a meiotic recombination hotspot on chromosome III of Saccharomyces cerevisiae.
    Genetics. 1991 Aug;128(4):717-27 PMID: 1840557
  15. Detailed physical map of human chromosomal region 11q12-13 shows high meiotic recombination rate around the MEN1 locus.
    Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10609-13 PMID: 1683706
  16. Two Alleles of Maize ALCOHOL DEHYDROGENASE 1 Have 3' Structural and Poly(a) Addition Polymorphisms.
    Genetics. 1986 Jun;113(2):449-67 PMID: 17246333
  17. Influence of transposable elements on the structure and function of the A1 gene of Zea mays.
    EMBO J. 1987 Feb;6(2):287-94 PMID: 15981326
  18. The relationship between genetic and physical distances in the cloned a1-sh2 interval of the Zea mays L. genome.
    Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8268-72 PMID: 8058793
  19. DIFFERENCE IN THE BEHAVIOR OF EU- AND HETERO-CHROMATIN: CROSSING-OVER.
    Nature. 1965 Feb 13;205:725-6 PMID: 14287435
  20. Special sites in generalized recombination.
    Annu Rev Genet. 1979;13:7-24 PMID: 395896
  21. Increased recombination frequencies resulting from directional selection for geotaxis in Drosophila.
    Heredity (Edinb). 1994 Jan;72 ( Pt 1):64-8 PMID: 8119830
  22. Identification and molecular characterization of shrunken-2 cDNA clones of maize.
    Plant Cell. 1990 Jun;2(6):581-8 PMID: 1967077
  23. Molecular basis of mutations at the waxy locus of maize: correlation with the fine structure genetic map.
    Proc Natl Acad Sci U S A. 1985 Jun;82(12):4177-81 PMID: 3858874
  24. Variable Patterns of Transposition of the Maize Element Activator in Tobacco.
    Plant Cell. 1991 May;3(5):473-482 PMID: 12324601
  25. Molecular characterization of rDt, a maize transposon of the "Dotted" controlling element system.
    Mol Gen Genet. 1989 Jan;215(2):239-44 PMID: 2540411
  26. The WAXY Locus in Maize. II. the Location of the Controlling Element Alleles.
    Genetics. 1968 Nov;60(3):507-24 PMID: 17248421
  27. Genetic Fine Structure of the BRONZE Locus in Maize.
    Genetics. 1986 Aug;113(4):1021-36 PMID: 17246338
  28. Ribosomal DNA spacer-length polymorphisms in barley: mendelian inheritance, chromosomal location, and population dynamics.
    Proc Natl Acad Sci U S A. 1984 Dec;81(24):8014-8 PMID: 6096873
  29. Double-strand breaks at an initiation site for meiotic gene conversion.
    Nature. 1989 Mar 2;338(6210):87-90 PMID: 2645528
  30. The Transposable Element Ds Affects the Pattern of Intragenic Recombination at the bz and R Loci in Maize.
    Genetics. 1986 May;113(1):135-43 PMID: 17246326
  31. Physical detection of heteroduplexes during meiotic recombination in the yeast Saccharomyces cerevisiae.
    Mol Cell Biol. 1993 Apr;13(4):2324-31 PMID: 8455614
Article Info
Journal
The Plant cell
Abbr.
Plant Cell
ISSN
1040-4651
DOI
10.1105/tpc.7.12.2151
Published
1995-12-00
Pages
2151-61
Language
English
Region
England
NLM ID
9208688
PMCID
PMC161069
Subset
IM
External Links
PubMed source DOI: 10.1105/tpc.7.12.2151 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2