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PMID: 8699127 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Endotoxin signal transduction in macrophages.

Journal of leukocyte biology ·Vol. 60 ·No. 1 ·1996-07-00 ·Pages 8-26

Sweet MJ, Hume DA

Abstract

Through its action on macrophages, bacterial lipopolysaccharide (LPS) or endotoxin can trigger responses that are protective or injurious to the host. This review examines the effects of LPS on macrophages by following events from the cell surface to the nucleus. The involvement of protein tyrosine kinases, mitogen-activated protein kinases, protein kinase C, G proteins, protein kinase A, ceramide-activated protein kinase, and microtubules in this process are reviewed. At the nuclear level, rel, C/EBP, Ets, Egr, fos, and jun family members have been implicated in activation of LPS-inducible gene expression.

MeSH Terms

Animals Base Sequence Binding Sites CCAAT-Enhancer-Binding Proteins Calcium-Calmodulin-Dependent Protein Kinases/metabolism Cell Membrane/physiology Cell Nucleus/physiology Consensus Sequence DNA-Binding Proteins/metabolism Early Growth Response Protein 1 Endotoxins/pharmacology GTP-Binding Proteins/metabolism Humans Immediate-Early Proteins Lipopolysaccharide Receptors/physiology Lipopolysaccharides/pharmacology Macrophages/drug effects,physiology Molecular Sequence Data Nuclear Proteins/metabolism Promoter Regions, Genetic Protein Kinases/metabolism Protein-Tyrosine Kinases/metabolism Proto-Oncogene Proteins/metabolism Proto-Oncogene Proteins c-ets Proto-Oncogene Proteins c-fos/metabolism Proto-Oncogene Proteins c-jun/metabolism Signal Transduction Transcription Factors/metabolism Transcription, Genetic/drug effects

Chemicals

CCAAT-Enhancer-Binding Proteins DNA-Binding Proteins EGR1 protein, human Early Growth Response Protein 1 Endotoxins Immediate-Early Proteins Lipopolysaccharide Receptors Lipopolysaccharides Nuclear Proteins Proto-Oncogene Proteins Proto-Oncogene Proteins c-ets Proto-Oncogene Proteins c-fos Proto-Oncogene Proteins c-jun Transcription Factors Protein Kinases Protein-Tyrosine Kinases Calcium-Calmodulin-Dependent Protein Kinases GTP-Binding Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Sweet M J

Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia.

Hume D A

Article Info

Journal

Journal of leukocyte biology

Abbr.

J Leukoc Biol

ISSN

0741-5400

DOI

10.1002/jlb.60.1.8

Published

1996-07-00

Pages

8-26

Language

English

Region

United States

NLM ID

8405628

Subset

External Links

PubMed source DOI: 10.1002/jlb.60.1.8 View journal details

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