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PMID: 8666675 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin.

The Journal of cell biology ·Vol. 133 ·No. 4 ·1996-05-00 ·Pages 921-8

Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, Farese RV, Sheppard D

Abstract

The integrin alpha v beta 6 is only expressed in epithelial cells. In healthy adult epithelia, this receptor is barely detectable, but expression is rapidly induced following epithelial injury. Mice homozygous for a null mutation in the gene encoding the beta 6 subunit had juvenile baldness associated with infiltration of macrophages into the skin, and accumulated activated lymphocytes around conducting airways in the lungs. Beta 6-/- mice also demonstrated airway hyperresponsiveness to acetylcholine, a hallmark feature of asthma. These results suggest that the epithelial integrin alpha v beta 6 participates in the modulation of epithelial inflammation. Genetic or acquired alterations in this integrin could thus contribute to the development of inflammatory diseases of epithelial organs, such as the lungs and skin.

MeSH Terms
Alopecia/genetics,immunology Animals Antigens, Neoplasm Base Sequence Cell Line Cell Movement Cells, Cultured DNA Primers Female Guinea Pigs Humans Inflammation Mediators/immunology Integrins/genetics,immunology Interferon-gamma/biosynthesis Interleukin-4/biosynthesis Keratinocytes/cytology,immunology Lung/cytology,immunology Lymphocyte Activation Lymphocytes/immunology Macrophages/immunology Male Mice Mice, Inbred C57BL Molecular Sequence Data Mutation Skin/cytology,immunology Stem Cells/cytology,immunology
Chemicals
Antigens, Neoplasm DNA Primers Inflammation Mediators Integrins integrin alphavbeta6 Interleukin-4 Interferon-gamma
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Huang X Z
Lung Biology Center, University of California, San Francisco 94143, USA.
Wu J F
Cass D
Erle D J
Corry D
Young S G
Farese R V
Sheppard D
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32 references, click to expand
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.133.4.921
Published
1996-05-00
Pages
921-8
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2120829
Subset
IM
Grants
NHLBI NIH HHS · HL/A133259 · United States
NHLBI NIH HHS · HL47412 · United States
NHLBI NIH HHS · HL53949 · United States
External Links
PubMed source DOI: 10.1083/jcb.133.4.921 PMC Full Text View journal details
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