On malleability in the genetic code.

Journal of molecular evolution ·Vol. 42 ·No. 5 ·1996-05-00 ·Pages 597-601

Schultz DW, Yarus M

Abstract

To explain now-numerous cases of codon reassignment (departure from the "universal" code), we suggest a pathway in which the transformed codon is temporarily ambiguous. All the unusual tRNA activities required have been demonstrated. In addition, the repetitive use of certain reassignments, the phylogenetic distribution of reassignments, and the properties of present-day reassinged tRNAs are each consistent with evolution of the code via an ambiguous translational intermediate.

MeSH Terms

Codon/genetics Evolution, Molecular Genetic Code Models, Genetic Protein Biosynthesis RNA, Transfer/genetics

Chemicals

Codon RNA, Transfer

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Schultz D W

Yarus M

References (25)

25 references, click to expand

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Article Info

Journal

Journal of molecular evolution

Abbr.

J Mol Evol

ISSN

0022-2844

DOI

10.1007/BF02352290

Published

1996-05-00

Pages

597-601

Language

English

Region

Germany

NLM ID

0360051

Subset

External Links

PubMed source DOI: 10.1007/BF02352290 View journal details

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On malleability in the genetic code.

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