Hepatitis C virus sequences encoding truncated core proteins detected in a hepatocellular carcinoma.

Biochemical and biophysical research communications ·Vol. 219 ·No. 3 ·1996-02-27 ·Pages 911-5

Rüster B, Zeuzem S, Roth WK

Abstract

RNA was specifically extracted from tumor and peritumor tissue of a hepatitis C virus (HCV)-associated hepatocellular carcinoma after microdissection. RT-PCR products of the HCV 5'-noncoding (NC), core and nonstructural (NS)-5 gene were examined. Nucleotide sequences of the core region derived from the tumor tissue revealed deletions and mutations resulting in truncated proteins. Peritumor and serum HCV sequences were unaffected.

MeSH Terms

Amino Acid Sequence Base Sequence Carcinoma, Hepatocellular/virology DNA Primers Genes, Viral Hepacivirus/genetics,isolation & purification Humans Liver Neoplasms/virology Male Middle Aged Molecular Sequence Data Mutation Polymerase Chain Reaction RNA, Viral/genetics,isolation & purification Sequence Deletion Viral Core Proteins/biosynthesis,genetics Viral Nonstructural Proteins/biosynthesis,genetics

Chemicals

DNA Primers RNA, Viral Viral Core Proteins Viral Nonstructural Proteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Rüster B

Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, Frankfurt a. M., Germany.

Zeuzem S

Roth W K

Article Info

Journal

Biochemical and biophysical research communications

Abbr.

Biochem Biophys Res Commun

ISSN

0006-291X

DOI

10.1006/bbrc.1996.0340

Published

1996-02-27

Pages

911-5

Language

English

Region

United States

NLM ID

0372516

Subset

External Links

PubMed source DOI: 10.1006/bbrc.1996.0340 View journal details

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Hepatitis C virus sequences encoding truncated core proteins detected in a hepatocellular carcinoma.

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