Home LiteratureArticle Details
PMID: 8644756 Published · ppublish English Comparative Study Letter Research Support, U.S. Gov't, P.H.S.

Affecteds-only linkage methods are not a panacea.

American journal of human genetics ·Vol. 58 ·No. 4 ·1996-04-00 ·Pages 892-5

Greenberg DA, Hodge SE, Vieland VJ, Spence MA

Abstract

暂无摘要

MeSH Terms
Family Genetic Linkage Humans Lod Score Models, Genetic Statistics, Nonparametric
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Greenberg D A
Hodge S E
Vieland V J
Spence M A
References (28)
28 references, click to expand
  1. Lods, wrods, and mods: the interpretation of lod scores calculated under different models.
    Genet Epidemiol. 1994;11(4):329-42 PMID: 7813895
  2. Using lod-score differences to determine mode of inheritance: a simple, robust method even in the presence of heterogeneity and reduced penetrance.
    Am J Hum Genet. 1994 Oct;55(4):834-40 PMID: 7942860
  3. The affected-pedigree-member method: power to detect linkage.
    Hum Hered. 1995 Jan-Feb;45(1):13-24 PMID: 7896296
  4. Model-free linkage analysis using likelihoods.
    Am J Hum Genet. 1995 Sep;57(3):703-16 PMID: 7668300
  5. Scanning chromosome 17 for psoriasis susceptibility: lack of evidence for a distal 17q locus.
    Hum Hered. 1995 Jul-Aug;45(4):219-30 PMID: 7558055
  6. Schizophrenia and GABAA receptor subunit genes.
    Psychiatr Genet. 1995 Spring;5(1):23-9 PMID: 7582877
  7. Mapping of genes predisposing to idiopathic generalized epilepsy.
    Hum Mol Genet. 1995 Jul;4(7):1201-7 PMID: 8528209
  8. TDT with covariates and genomic screens with mod scores: their behavior on simulated data.
    Genet Epidemiol. 1995;12(6):659-64 PMID: 8787990
  9. Evaluation of screening strategies to detect an oligogenic disease.
    Genet Epidemiol. 1995;12(6):665-9 PMID: 8787991
  10. Genetic analysis of a common oligogenic trait with quantitative correlates: summary of GAW9 results.
    Genet Epidemiol. 1995;12(6):689-706 PMID: 8787995
  11. Inherent intractability of the ascertainment problem for pedigree data: a general likelihood framework.
    Am J Hum Genet. 1995 Jan;56(1):33-43 PMID: 7825595
  12. Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene.
    Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5918-21 PMID: 8016089
  13. The investigation of linkage between a quantitative trait and a marker locus.
    Behav Genet. 1972 Mar;2(1):3-19 PMID: 4157472
  14. Effects of misspecifying genetic parameters in lod score analysis.
    Biometrics. 1986 Jun;42(2):393-9 PMID: 3741977
  15. The affected-pedigree-member method of linkage analysis.
    Am J Hum Genet. 1988 Feb;42(2):315-26 PMID: 3422543
  16. Juvenile myoclonic epilepsy (JME) may be linked to the BF and HLA loci on human chromosome 6.
    Am J Med Genet. 1988 Sep;31(1):185-92 PMID: 3146924
  17. Linkage analysis under "random" and "genetic" reduced penetrance.
    Genet Epidemiol. 1989;6(1):259-64 PMID: 2786485
  18. Inferring mode of inheritance by comparison of lod scores.
    Am J Med Genet. 1989 Dec;34(4):480-6 PMID: 2624256
  19. Man bites dog? The validity of maximizing lod scores to determine mode of inheritance.
    Am J Med Genet. 1989 Dec;34(4):487-8 PMID: 2624257
  20. Measuring the inflation of the lod score due to its maximization over model parameter values in human linkage analysis.
    Genet Epidemiol. 1990;7(4):237-43 PMID: 2227370
  21. On the asymptotic behavior of the estimate of the recombination fraction under the null hypothesis of no linkage when the model is misspecified.
    Genet Epidemiol. 1990;7(5):309-18 PMID: 2253866
  22. Localization of idiopathic generalized epilepsy on chromosome 6p in families of juvenile myoclonic epilepsy patients.
    Neurology. 1991 Oct;41(10):1651-5 PMID: 1922810
  23. Adequacy of single-locus approximations for linkage analyses of oligogenic traits.
    Genet Epidemiol. 1992;9(1):45-59 PMID: 1634106
  24. Strategies based on marker information for the study of human diseases.
    Ann Hum Genet. 1992 May;56(Pt 2):145-53 PMID: 1503394
  25. Better data analysis through data exploration.
    Am J Hum Genet. 1993 Sep;53(3):775-7 PMID: 8352283
  26. Two-locus models of disease: comparison of likelihood and nonparametric linkage methods.
    Am J Hum Genet. 1993 Oct;53(4):908-15 PMID: 8213819
  27. Adequacy of single-locus approximations for linkage analyses of oligogenic traits: extension to multigenerational pedigree structures.
    Hum Hered. 1993 Nov-Dec;43(6):329-36 PMID: 8288263
  28. Linkage analysis in nuclear families. 2: Relationship between affected sib-pair tests and lod score analysis.
    Hum Hered. 1994 Jan-Feb;44(1):44-51 PMID: 8163291
Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1996-04-00
Pages
892-5
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1914670
Subset
IM
Grants
NIDDK NIH HHS · DK31775 · United States
NIMH NIH HHS · MH36197 · United States
NINDS NIH HHS · NS27941 · United States
Corrections
CommentIn
PMID: 9042936
CommentIn
PMID: 9246012
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2