Home LiteratureArticle Details
PMID: 8629025 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Genetically engineered resistance to dengue-2 virus transmission in mosquitoes.

Science (New York, N.Y.) ·Vol. 272 ·No. 5263 ·1996-05-10 ·Pages 884-6

Olson KE, Higgs S, Gaines PJ, Powers AM, Davis BS, Kamrud KI, Carlson JO, Blair CD, Beaty BJ

Abstract

The control of arthropod-borne virus diseases such as dengue may ultimately require the genetic manipulation of mosquito vectors to disrupt virus transmission to human populations. To reduce the ability of mosquitoes to transmit dengue viruses, a recombinant Sindbis virus was used to transduce female Aedes aegypti with a 567-base antisense RNA targeted to the premembrane coding region of dengue type 2 (DEN-2) virus. The transduced mosquitoes were unable to support replication of DEN-2 virus in their salivary glands and therefore were not able to transmit the virus.

MeSH Terms
Aedes/genetics,virology Animals Dengue/transmission Dengue Virus/genetics,physiology Digestive System/virology Female Genetic Engineering Genetic Vectors Genome, Viral Humans Insect Vectors/genetics,virology RNA, Antisense/genetics Salivary Glands/virology Sindbis Virus/genetics Virus Replication
Chemicals
RNA, Antisense
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Olson K E
Arthropod-Borne and Infectious Diseases Laboratory (AIDL), Department of Microbiology, Colorado State University, Fort Collins 80523, USA.
Higgs S
Gaines P J
Powers A M
Davis B S
Kamrud K I
Carlson J O
Blair C D
Beaty B J
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.272.5263.884
Published
1996-05-10
Pages
884-6
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NIAID NIH HHS · AI07352 · United States
NIAID NIH HHS · AI34014 · United States
Corrections
CommentIn
PMID: 8629013
External Links
PubMed source DOI: 10.1126/science.272.5263.884 View journal details
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