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PMID: 8614801 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Adaptive evolution of human immunodeficiency virus-type 1 during the natural course of infection.

Science (New York, N.Y.) ·Vol. 272 ·No. 5261 ·1996-04-26 ·Pages 537-42

Wolinsky SM, Korber BT, Neumann AU, Daniels M, Kunstman KJ, Whetsell AJ, Furtado MR, Cao Y, Ho DD, Safrit JT

Abstract

The rate of progression to disease varies considerably among individuals infected with human immunodeficiency virus-type 1 (HIV-1). Analyses of semiannual blood samples obtained from six infected men showed that a rapid rate of CD4 T cell loss was associated with relative evolutionary stasis of the HIV-1 quasispecies virus population. More moderate rates of CD4 T cell loss correlated with genetic evolution within three of four subjects. Consistent with selection by the immune constraints of these subjects, amino acid changes were apparent within the appropriate epitopes of human leukocyte antigen class I-restricted cytotoxic T lymphocytes. Thus, the evolutionary dynamics exhibited by the HIV-1 quasispecies virus populations under natural selection are compatible with adaptive evolution.

MeSH Terms

Acquired Immunodeficiency Syndrome/immunology,virology Amino Acid Sequence Animals Antigenic Variation Base Sequence Biological Evolution CD4 Lymphocyte Count Cohort Studies Disease Progression HIV Antibodies/immunology HIV Antigens/immunology HIV Infections/immunology,virology HIV-1/genetics,immunology,pathogenicity,physiology Histocompatibility Antigens Class I/immunology Humans Male Mice Mice, SCID Molecular Sequence Data Mutation Phenotype RNA, Viral/blood T-Lymphocytes, Cytotoxic/immunology Virulence Virus Replication

Chemicals

HIV Antibodies HIV Antigens Histocompatibility Antigens Class I RNA, Viral

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Wolinsky S M

Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA.

Korber B T

Neumann A U

Daniels M

Kunstman K J

Whetsell A J

Furtado M R

Cao Y

Ho D D

Safrit J T

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.272.5261.537

Published

1996-04-26

Pages

537-42

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIAID NIH HHS · AI32535 · United States

NIAID NIH HHS · AI35522 · United States

NIAID NIH HHS · AI45218 · United States

Databases

GENBANK

U35955, U35956, U35957, U35958, U35959, U35960, U35961, U35962, U35963, U35964, U35965, U35966, U35967, U35968, U35969, U35970, U35971, U35972, U35973, U35974, U36115, U36116, U36117, U36118, U36119, U36120, U36121, U36122, U36123, U36124

Corrections

CommentIn

PMID: 8614796

CommentIn

PMID: 8658174

CommentIn

PMID: 8966557

External Links

PubMed source DOI: 10.1126/science.272.5261.537 View journal details

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Adaptive evolution of human immunodeficiency virus-type 1 during the natural course of infection.

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