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题目:: Sensitivity of multidrug-resistant tumor cell lines to immunologic effector cells.
作者:: Schmidt-Wolf(I G),Lefterova(P),Johnston(V),Scheffold(C),Csipai(M),Mehta(B A),Tsuruo(T),Huhn(D),Negrin(R S)
状态:: 发布时间1996-06-05 , 更新时间 2008-11-21
期刊:: Cell Immunol
摘要:: The ability of malignant cells to survive exposure to cytotoxic agents is a major obstacle to cure in patients with cancer. Multidrug resistance and the expression of P-glycoprotein are emerging as a cause of chemotherapy failure. Immunologic effector cells such as lymphokine-activated killer (LAK) cells or cytokine-induced killer (CIK) cells are capable of killing a broad range of tumor cell lines or freshly isolated tumor cells. As demonstrated here, LAK, and CIK cells possess a high level of cytotoxic activity against tumor cell lines both resistant and sensitive to chemotherapeutic agents such as doxorubicin or vinblastine. CIK cells possessed a higher level of cytotoxic activity than LAK cells as determined by 51Cr release and a tumor colony assay. Monoclonal antibodies against P-glycoprotein did not block the lysis of tumor cells resistant to chemotherapy by CIK cells. In contrast, antibodies to LFA-1 and ICAM-1 blocked CIK cell-mediated tumor cell lysis. These data demonstrate that immunological approaches to cancer therapy may be useful in overcoming disease caused by drug resistance.
语言:: eng
DOI:: 10.1006/cimm.1996.0094

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