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PMID: 8605242 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Cloning of a putative gamma-aminobutyric acid (GABA) receptor subunit rho 3 cDNA.

Biochimica et biophysica acta ·Vol. 1305 ·No. 1-2 ·1996-02-07 ·Pages 15-8

Ogurusu T, Shingai R

Abstract

Cloned cDNA encoding a putative member of GABA receptor rho-subunit class was isolated from rat-retina-mRNA-derived libraries. The cDNA encodes a signal peptide of 21 amino acids followed by the mature rho 3 subunit sequence of 443 amino acids. The proposed amino acid sequence exhibits 63 and 61% homology to the previously-reported human rho 1 and rat rho 2 sequences, respectively. Northern blot analysis demonstrated the expression of mRNA for rho 3 subunit in retina.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Cloning, Molecular DNA, Complementary/genetics Gene Library Humans Molecular Sequence Data Protein Conformation Protein Sorting Signals/genetics RNA, Messenger/genetics,metabolism Rats Receptors, GABA/chemistry,genetics Receptors, GABA-A Retina/metabolism Sequence Homology, Amino Acid Species Specificity

Chemicals

DNA, Complementary Gabrr3 protein, rat Protein Sorting Signals RNA, Messenger Receptors, GABA Receptors, GABA-A

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Ogurusu T

Department of Computer and Information Science, Faculty of Engineering, Iwate University, Morioka, Japan.

Shingai R

Article Info

Journal

Biochimica et biophysica acta

Abbr.

Biochim Biophys Acta

ISSN

0006-3002

DOI

10.1016/0167-4781(95)00205-7

Published

1996-02-07

Pages

15-8

Language

English

Region

Netherlands

NLM ID

0217513

Subset

Databases

GENBANK

D50671

External Links

PubMed source DOI: 10.1016/0167-4781(95)00205-7

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Cloning of a putative gamma-aminobutyric acid (GABA) receptor subunit rho 3 cDNA.

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