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PMID: 8601494 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Molecular analysis of 36 mutations at the mouse pink-eyed dilution (p) locus.

Genetics ·Vol. 141 ·No. 4 ·1995-12-00 ·Pages 1563-71

Johnson DK, Stubbs LJ, Culiat CT, Montgomery CS, Russell LB, Rinchik EM

Abstract

Thirty-six radiation- or chemically induced homozygous-lethal mutations at the p locus in mouse chromosome 7 have been analyzed at 17 loci defined by molecular probes to determine the types of lesions, numbers of p-region markers deleted or rearranged, regions of overlap of deletion mutations, and genetic distances between loci. A linear deletion map of the [Myod1, Ldh3]-[Snrpn, Znf127] region has been constructed from the molecular analyses of the p-locus deletions. The utility of these deletions as tools for the isolation and characterization of the genes specifying the neurological, reproductive, and developmental phenotypes genetically mapped to this region will grow as more detailed molecular analyses continue.

MeSH Terms
Animals Base Sequence Carrier Proteins Chromosome Mapping DNA Probes Female Homozygote Humans Male Membrane Proteins/genetics Membrane Transport Proteins Mice Molecular Sequence Data Mutation Phenotype Sequence Deletion
Chemicals
Carrier Proteins DNA Probes Membrane Proteins Membrane Transport Proteins OCA2 protein, human P protein, mouse
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Johnson D K
Biology Division, Oak Ridge National Laboratory, Tennessee 37831-8077, USA. johnsondk@bioaxl.bio.ornl.gov
Stubbs L J
Culiat C T
Montgomery C S
Russell L B
Rinchik E M
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/141.4.1563
Email
johnsondk@bioaxl.bio.ornl.gov
Published
1995-12-00
Pages
1563-71
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1206887
Subset
IM
External Links
PubMed source DOI: 10.1093/genetics/141.4.1563 PMC Full Text View journal details
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