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PMID: 8599672 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Hydration of the DNA bases is local.

Biophysical journal ·Vol. 69 ·No. 6 ·1995-12-00 ·Pages 2661-9

Schneider B, Berman HM

Abstract

Ordered hydration sites were determined for the nucleotide bases in B-type conformations using the crystal structure data on 14 B-DNA decamer structures. A method of density representation was extended so that positions, occupancies, and distributions of the hydration sites were predicted around a B-DNA double helix by a method analogous to crystallographic refinement. The predicted hydration sites correctly reproduce the main features of hydration around the B-DNA dodecamer. In contrast to the previous observations, the newly available crystal data show the same extent of hydration of guanine and adenine, and of cytosine and thymine.

MeSH Terms
Adenine Base Sequence Crystallography, X-Ray Cytosine DNA/chemistry Databases, Factual Guanine Hydrogen Bonding Models, Molecular Molecular Sequence Data Nucleic Acid Conformation Oligodeoxyribonucleotides/chemistry Thymine
Chemicals
Oligodeoxyribonucleotides Guanine Cytosine DNA Adenine Thymine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Schneider B
J. Heyrovsky Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Berman H M
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28 references, click to expand
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Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(95)80136-0
Published
1995-12-00
Pages
2661-9
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1236503
Subset
IM
Grants
NIGMS NIH HHS · GM21589 · United States
External Links
PubMed source DOI: 10.1016/S0006-3495(95)80136-0 PMC Full Text View journal details
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