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PMID: 8597630 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A high-resolution genetic map of mouse chromosome 15 encompassing the Dominant megacolon (Dom) locus.

Mammalian genome : official journal of the International Mammalian Genome Society ·Vol. 6 ·No. 11 ·1995-11-00 ·Pages 763-8

Puliti A, Prehu MO, Simon-Chazottes D, Ferkdadji L, Peuchmaur M, Goossens M, Guénet JL

Abstract

Dominant megacolon (Dom) is one of four mutations in the mouse that can produce a phenotype similar to Hirschsprung disease in human. The Dom gene product is not known, and no candidate region has been defined for a possible human homolog. In this publication we report mapping the Dom locus with high definition, using several intra-and interspecific crosses and a set of 16 Chr 15-specific microsatellites flanking this locus.

MeSH Terms
Animals Chromosome Mapping/methods Crosses, Genetic Female Hirschsprung Disease/genetics Male Mice Mice, Mutant Strains Microsatellite Repeats Mutation
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Puliti A
Unité INSERM U91. Hôpital Henri Mondor, Créil, France.
Prehu M O
Simon-Chazottes D
Ferkdadji L
Peuchmaur M
Goossens M
Guénet J L
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Article Info
Journal
Mammalian genome : official journal of the International Mammalian Genome Society
Abbr.
Mamm Genome
ISSN
0938-8990
DOI
10.1007/BF00539000
Published
1995-11-00
Pages
763-8
Language
English
Region
United States
NLM ID
9100916
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00539000 View journal details
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