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题目:: Clustering of Cx43 cell-to-cell channels into gap junction plaques: regulation by cAMP and microfilaments.
作者:: Wang(Y),Rose(B)
状态:: 发布时间1996-03-25 , 更新时间 2013-11-21
期刊:: J Cell Sci
摘要:: Cell-to-cell channels are often seen clustered at cell-cell contacts into the so-called gap junction plaques. The mechanism of this clustering is unknown. We show that the clustering of cell-to-cell channels composed of connexin43 is induced by elevation of cyclic AMP. The cAMP-induced clustering is enhanced by inhibition of glycosylation and abolished by disruption of microfilaments. Channel clustering thus seems to be regulated by cAMP and glycosylation and to involve microfilaments.
语言:: eng
DOI:

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