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PMID: 8582635 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Evolutionary origin of nonuniversal CUGSer codon in some Candida species as inferred from a molecular phylogeny.

Genetics ·Vol. 141 ·No. 3 ·1995-11-00 ·Pages 903-7

Pesole G, Lotti M, Alberghina L, Saccone C

Abstract

CUG, a universal leucine codon, has been reported to be read as serine in various yeast species belonging to the genus Candida. To gain a deeper insight into the origin of this deviation from the universal genetic code, we carried out a phylogenetic analysis based on the small-subunit ribosomal RNA genes from some Candida and other related Hemiascomycetes. Furthermore, we determined the phylogenetic relationships between the tRNA(Ser)CAG, responsible for the translation of CUG, from some Candida species and the other serine and leucine isoacceptor tRNAs in C. cylindracea. We demonstrate that the group of Candida showing the genetic code deviation is monophyletic and that this deviation could have originated more than 150 million years ago. We also describe how phylogenetic analysis can be used for genetic code predictions.

MeSH Terms
Ascomycota/classification,genetics Base Sequence Candida/classification,genetics Codon DNA, Fungal/genetics DNA, Ribosomal/genetics Evolution, Molecular Genes, Fungal Genetic Code Molecular Sequence Data Phylogeny RNA, Fungal/genetics RNA, Ribosomal, 18S/genetics RNA, Transfer, Leu/genetics RNA, Transfer, Ser/genetics Sequence Alignment Sequence Homology, Nucleic Acid Serine Species Specificity
Chemicals
Codon DNA, Fungal DNA, Ribosomal RNA, Fungal RNA, Ribosomal, 18S RNA, Transfer, Leu RNA, Transfer, Ser Serine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Pesole G
Dipartimento di Biochimica e Biologia Molecolare, Università di Bari, Italy.
Lotti M
Alberghina L
Saccone C
References (11)
11 references, click to expand
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/141.3.903
Published
1995-11-00
Pages
903-7
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1206853
Subset
IM
Databases
GENBANK
D12940, D12941, D13706, D14890, D14980, D17533, D17534, D26074, J01353, M55526, M55527, M55528, M60303, M60304, M60307, M60308, M60309, M60310, M60312, S42406, X04971, X51830, X51831, X53497, X58054, X58055, X58056, X69842
PIR
D14593
External Links
PubMed source DOI: 10.1093/genetics/141.3.903 PMC Full Text View journal details
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