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PMID: 8573350 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression.

Current opinion in cell biology ·Vol. 7 ·No. 5 ·1995-10-00 ·Pages 736-47

Roskelley CD, Srebrow A, Bissell MJ

Abstract

A dynamic and reciprocal flow of information between cells and the extracellular matrix contributes significantly to the regulation of form and function in developing systems. Signals generated by the extracellular matrix do not act in isolation. Instead, they are processed within the context of global signalling hierarchies whose constituent inputs and outputs are constantly modulated by all the factors present in the cell's surrounding microenvironment. This is particularly evident in the mammary gland, where the construction and subsequent destruction of such a hierarchy regulates changes in tissue-specific gene expression, morphogenesis and apoptosis during each developmental cycle of pregnancy, lactation and involution.

MeSH Terms
Animals Cell Division Extracellular Matrix/genetics,physiology Female Gene Expression/genetics Mammary Glands, Animal/growth & development,physiology Morphogenesis/genetics,physiology Pregnancy Signal Transduction/genetics,physiology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Roskelley C D
Srebrow A
Bissell M J
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
0955-0674
DOI
10.1016/0955-0674(95)80117-0
Published
1995-10-00
Pages
736-47
Language
English
Region
England
NLM ID
8913428
PMCID
PMC2933201
Subset
IM
Grants
NCI NIH HHS · R01 CA057621 · United States
NCI NIH HHS · R01 CA057621-07 · United States
NCI NIH HHS · CA 57621-02 · United States
External Links
PubMed source DOI: 10.1016/0955-0674(95)80117-0 PMC Full Text View journal details
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