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PMID: 8570608 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Cell cycling and patterned cell proliferation in the wing primordium of Drosophila.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 93 ·No. 2 ·1996-01-23 ·Pages 640-5

Milán M, Campuzano S, García-Bellido A

Abstract

The pattern of cell proliferation in the Drosophila imaginal wing primordium is spatially and temporally heterogeneous. Direct visualization of cells in S, G2, and mitosis phases of the cell cycle reveals several features invariant throughout development. The fraction of cells in the disc in the different cell cycle stages is constant, the majority remaining in G1. Cells in the different phases of the cell cycle mainly appear in small synchronic clusters that are nonclonally derived but result from changing local cell-cell interactions. Cluster synchronization occurs before S and in the G2/M phases. Rates of cell division are neither constant nor clonal features. Cell cycle progression is linear rather than concentric. Clusters appear throughout the disc but with symmetries related to presumptive wing patterns, compartment boundaries, and vein clonal restrictions.

MeSH Terms
Animals Apoptosis Cell Cycle/physiology Cell Cycle Proteins Clone Cells Drosophila/embryology Drosophila Proteins G2 Phase Microscopy, Fluorescence Mitosis Phosphoprotein Phosphatases/biosynthesis Protein Tyrosine Phosphatases S Phase Wings, Animal/embryology
Chemicals
Cell Cycle Proteins Drosophila Proteins Phosphoprotein Phosphatases Protein Tyrosine Phosphatases stg protein, Drosophila
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Milán M
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
Campuzano S
García-Bellido A
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.93.2.640
Published
1996-01-23
Pages
640-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC40104
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.93.2.640 PMC Full Text View journal details
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