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PMID: 8570600 Published · ppublish English Journal Article

Cell fate determination in the vertebrate retina.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 93 ·No. 2 ·1996-01-23 ·Pages 589-95

Cepko CL, Austin CP, Yang X, Alexiades M, Ezzeddine D

Abstract

In the vertebrate central nervous system, the retina has been a useful model for studies of cell fate determination. Recent results from studies conducted in vitro and in vivo suggest a model of retinal development in which both the progenitor cells and the environment change over time. The model is based upon the notion that the mitotic cells within the retina change in their response properties, or "competence", during development. These changes presage the ordered appearance of distinct cell types during development and appear to be necessary for the production of the distinct cell types. As the response properties of the cells change, so too do the environmental signals that the cells encounter. Together, intrinsic properties and extrinsic cues direct the choice of cell fate.

MeSH Terms
Animals Chickens Mice Models, Biological Rats Retina/cytology,embryology Retinal Ganglion Cells Retinal Rod Photoreceptor Cells/embryology Stem Cells
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Cepko C L
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Austin C P
Yang X
Alexiades M
Ezzeddine D
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.93.2.589
Published
1996-01-23
Pages
589-95
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC40096
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.93.2.589 PMC Full Text View journal details
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