[The significance of high-density lipoprotein subfractions and triglycerides in predicting coronary artery disease].

Serum Lipid profiles, including high-density lipoprotein (HDL) and its subfractions HDL2 and HDL3 were obtained in 78 cases undergoing coronary angiography. Coronary artery disease (CAD) was present in 51 patients and absent in 27. We used a scoring methold of CAD to reflect the extent or narrowing of coronary artery. The largest difference between the two groups was observed in HDL2 Cholesterol with a mean of 0.37 mmol/L in patients with CAD as compared with 0.49 mmol/L in normal subjects (P < 0.001) and in TG (1.85 mmol/L vs 1.16 mmol/L) as well. Smaller difference was found in TC (5.9 mmol/L vs 4.87 mmol/L, P < 0.05). No singnificant difference was found in serum HDL (P > 0.05). Multivariate regression analysis revealed that the most powerful indenpendent variable associated with the extent of CAD was HDL2 cholesterol and triglyceride. The score of CAD was significantly correlated with HDL2-c (r = 0.32 P < 0.01) and TG (r = 0.34 P < 0.01). It is shown that high serum level of TG (> 1.6 mmol/L) and low serum level of HDLC2 (< 0.37 mmol/L) were the strengest predictors of presence and extent of CAD.