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PMID: 8560265 Published · ppublish English Journal Article

Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent.

Science (New York, N.Y.) ·Vol. 271 ·No. 5248 ·1996-01-26 ·Pages 505-8

Linnen J, Wages J, Zhang-Keck ZY, Fry KE, Krawczynski KZ, Alter H, Koonin E, Gallagher M, Alter M, Hadziyannis S, Karayiannis P, Fung K, Nakatsuji Y, Shih JW, Young L, Piatak M, Hoover C, Fernandez J, Chen S, Zou JC, Morris T, Hyams KC, Ismay S, Lifson JD, Hess G, Foung SK, Thomas H, Bradley D, Margolis H, Kim JP

Abstract

An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis. Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.

MeSH Terms

Acute Disease Amino Acid Sequence Base Sequence Blood Donors Blood-Borne Pathogens Chronic Disease Cloning, Molecular Consensus Sequence Disease Transmission, Infectious Flaviviridae/genetics Genome, Viral Hepatitis Viruses/chemistry,genetics,isolation & purification Hepatitis, Viral, Human/epidemiology,transmission,virology Humans Molecular Sequence Data Polymerase Chain Reaction RNA Viruses/chemistry,genetics,isolation & purification RNA, Viral/blood,genetics Sequence Alignment Transfusion Reaction United States/epidemiology Viral Proteins/chemistry,genetics Viremia/epidemiology,virology

Chemicals

RNA, Viral Viral Proteins

Authors & Affiliations

30 authors, click to expand affiliations / ORCID

Linnen J

Genelabs Technologies, Redwood City, CA 94063, USA.

Wages J

Zhang-Keck Z Y

Fry K E

Krawczynski K Z

Alter H

Koonin E

Gallagher M

Alter M

Hadziyannis S

Karayiannis P

Fung K

Nakatsuji Y

Shih J W

Young L

Piatak M

Hoover C

Fernandez J

Chen S

Zou J C

Morris T

Hyams K C

Ismay S

Lifson J D

Hess G

Foung S K

Thomas H

Bradley D

Margolis H

Kim J P

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.271.5248.505

Published

1996-01-26

Pages

505-8

Language

English

Region

United States

NLM ID

0404511

Subset

Databases

GENBANK

AB000137, AB000138, AB000139, AB000140, AB000141, AB000142, AB000143, AB000144, AB000145, AB000146, AB000147, AB000148, AB000149, AB000150, AB000151, AB000152, AB000153, AB000154, AB000155, AB000156, AB000157, AB000158, AB000159, AB000160, AB000161, AB000162, AB000163

External Links

PubMed source DOI: 10.1126/science.271.5248.505 View journal details

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Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent.

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