Nucleotide excision repair and the link with transcription.

Trends in biochemical sciences ·Vol. 20 ·No. 10 ·1995-10-00 ·Pages 402-5

Lehmann AR

Abstract

Nucleotide excision repair (NER) uses the products of about 30 genes to remove a damage-containing oligonucleotide from cellular DNA. The transcription factor TFIIH is an essential component of NER. In man, defects in NER can result in three distinct genetic disorders, whose features can be ascribed to abnormalities in DNA repair or transcription.

MeSH Terms

Cockayne Syndrome/genetics DNA Repair Hair/abnormalities Humans Models, Genetic Nucleotides Transcription Factor TFIIH Transcription Factors/genetics Transcription Factors, TFII Transcription, Genetic Xeroderma Pigmentosum/genetics

Chemicals

Nucleotides Transcription Factors Transcription Factors, TFII Transcription Factor TFIIH

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Lehmann A R

MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, UK.

Article Info

Journal

Trends in biochemical sciences

Abbr.

Trends Biochem Sci

ISSN

0968-0004

DOI

10.1016/s0968-0004(00)89088-x

Published

1995-10-00

Pages

402-5

Language

English

Region

England

NLM ID

7610674

Subset

External Links

PubMed source DOI: 10.1016/s0968-0004(00)89088-x View journal details

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