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PMID: 8516848 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Transcriptional regulation of multigene loci: multilevel control.

Trends in genetics : TIG ·Vol. 9 ·No. 4 ·1993-04-00 ·Pages 134-7

Dillon N, Grosveld F

Abstract

Recent studies indicate that different levels of control operate within multigene loci. In addition to regulatory sequences immediately flanking the genes, there are also elements that act over long distances on more than one gene. Competition for these elements among genes can influence both the level and timing of gene expression during development.

MeSH Terms
Animals Gene Expression Regulation Genes, Regulator/physiology Humans Mice Multigene Family Regulatory Sequences, Nucleic Acid Transcription, Genetic
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dillon N
Laboratory of Gene Structure and Expression, MRC National Institute for Medical Research, Mill Hill, London, UK.
Grosveld F
Article Info
Journal
Trends in genetics : TIG
Abbr.
Trends Genet
ISSN
0168-9525
DOI
10.1016/0168-9525(93)90208-y
Published
1993-04-00
Pages
134-7
Language
English
Region
England
NLM ID
8507085
Subset
IM
External Links
PubMed source DOI: 10.1016/0168-9525(93)90208-y View journal details
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