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PMID: 8513101 Published · ppublish English Journal Article

On the irreducibility of a Markov chain defined on a space of genotype configurations by a sampling scheme.

Biometrics ·Vol. 49 ·No. 1 ·1993-03-00 ·Pages 163-75

Sheehan N, Thomas A

Abstract

Techniques from image processing are now being considered for use in pedigree analysis. Although the method that we develop here was motivated by considering it as an analogue to the Gibbs sampler, we justify it independently using the ergodic theorem for aperiodic, irreducible, finite Markov chains. While it is trivial to show that aperiodicity holds, irreducibility is a more interesting condition. Proofs of irreducibility are provided for some special cases and counterexamples are provided for others. Where irreducibility does not hold, an alternative method using relaxed genetic parameters and rejection is recommended and justified.

MeSH Terms
Alleles Animals Biometry Computer Simulation Female Genotype Humans Male Markov Chains Models, Genetic Models, Statistical Pedigree Phenotype Reproducibility of Results
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sheehan N
School of Mathematical Sciences, University of Bath, Claverton Down, England.
Thomas A
Article Info
Journal
Biometrics
Abbr.
Biometrics
ISSN
0006-341X
Published
1993-03-00
Pages
163-75
Language
English
Region
United States
NLM ID
0370625
Subset
IM
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