Combinatorial infection and in vivo recombination: a strategy for making large phage antibody repertoires.

Nucleic acids research ·Vol. 21 ·No. 9 ·1993-05-11 ·Pages 2265-6

Waterhouse P, Griffiths AD, Johnson KS, Winter G

Abstract

暂无摘要

MeSH Terms

Amino Acid Sequence Bacteriophage P1/genetics Base Sequence Cloning, Molecular/methods DNA, Recombinant/genetics Escherichia coli Humans Immunoglobulin Heavy Chains/genetics Immunoglobulin Light Chains/genetics Molecular Sequence Data Oligodeoxyribonucleotides

Chemicals

DNA, Recombinant Immunoglobulin Heavy Chains Immunoglobulin Light Chains Oligodeoxyribonucleotides

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Waterhouse P

MRC Centre for Protein Engineering, MRC Centre, Cambridge, UK.

Griffiths A D

Johnson K S

Winter G

References (16)

16 references, click to expand

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Human anti-self antibodies with high specificity from phage display libraries.
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Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.
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The role of the loxP spacer region in P1 site-specific recombination.
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Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda.
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Phage antibodies: filamentous phage displaying antibody variable domains.
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Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains.
Nucleic Acids Res. 1991 Aug 11;19(15):4133-7 PMID: 1908075
By-passing immunization. Human antibodies from V-gene libraries displayed on phage.
J Mol Biol. 1991 Dec 5;222(3):581-97 PMID: 1748994
By-passing immunization: building high affinity human antibodies by chain shuffling.
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Selective enhancement of the tumour necrotic activity of TNF alpha with monoclonal antibody.
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Article Info

Journal

Nucleic acids research

Abbr.

Nucleic Acids Res

ISSN

0305-1048

DOI

10.1093/nar/21.9.2265

Published

1993-05-11

Pages

2265-6

Language

English

Region

England

NLM ID

0411011

PMCID

PMC309506

Subset

External Links

PubMed source DOI: 10.1093/nar/21.9.2265 PMC Full Text View journal details

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Combinatorial infection and in vivo recombination: a strategy for making large phage antibody repertoires.

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