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PMID: 8500598 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Nervous tissue proteoglycans.

Experientia ·Vol. 49 ·No. 5 ·1993-05-15 ·Pages 429-46

Margolis RK, Margolis RU

Abstract

The structure, biosynthesis, localization, and possible functional roles of nervous tissue glycosaminoglycans and proteoglycans were last reviewed several years ago. Since that time, there has been an exponential increase in publications on the neurobiology of proteoglycans. This review will therefore focus on reports which have appeared in the period after 1988, and especially on those concerning the properties of individual characterized nervous tissue proteoglycans. Related areas such as the regulation of glycosaminoglycan biosynthesis and the roles of cell surface proteoglycans in adhesion and growth control are covered in other contributions to this special topic issue.

MeSH Terms
Amyloid beta-Peptides/metabolism Animals Brain/metabolism Cell Adhesion Molecules, Neuronal/metabolism Chondroitin Sulfate Proteoglycans/metabolism Chromogranins/metabolism Glycosylphosphatidylinositols/metabolism Heparitin Sulfate/metabolism Humans Keratan Sulfate/metabolism Lectins, C-Type Membrane Glycoproteins/metabolism Nerve Tissue Proteins/physiology Nervous System Physiological Phenomena Neurites/ultrastructure Proteoglycans/metabolism,physiology Synaptic Membranes/metabolism Synaptic Vesicles/metabolism Syndecans Versicans
Chemicals
Amyloid beta-Peptides Cell Adhesion Molecules, Neuronal Chondroitin Sulfate Proteoglycans Chromogranins Glycosylphosphatidylinositols Lectins, C-Type Membrane Glycoproteins Nerve Tissue Proteins Proteoglycans Syndecans VCAN protein, human Versicans Heparitin Sulfate Keratan Sulfate
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Margolis R K
Department of Pharmacology, State University of New York, Brooklyn 11203.
Margolis R U
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Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF01923587
Published
1993-05-15
Pages
429-46
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
Grants
NIMH NIH HHS · MH-00129 · United States
NINDS NIH HHS · NS-09348 · United States
NINDS NIH HHS · NS-13876 · United States
External Links
PubMed source DOI: 10.1007/BF01923587
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