Monocyte-mediated restoration of density-dependent growth control and induction of cell death in tumor cell populations.
作者:
Rüller(S),van der Bosch(J),Horn(D),Schlaak(M)
状态:
发布时间1993-06-29
, 更新时间 2013-11-21
期刊:
Exp Cell Res
摘要:
It is shown in a serum-free system with human cells that during monocyte/tumor cell interactions signals are generated which restore the principles of density-dependent inhibition of growth in tumor cell populations. Tumor cells that fail to comply with these principles are induced to die. This cell death is an active process in target cells involving protein biosynthesis and tumor cell-derived signals.