In vitro antimicrobial activity of a new antibiotic, MDL 62,879 (GE2270 A).

Antimicrobial agents and chemotherapy ·Vol. 37 ·No. 4 ·1993-04-00 ·Pages 741-5

Goldstein BP, Berti M, Ripamonti F, Resconi A, Scotti R, Denaro M

Abstract

MDL 62,879 (GE2270 A) is a new peptide antibiotic that inhibits protein synthesis through an interaction with elongation factor Tu. MDL 62,879 was very active against gram-positive clinical isolates, particularly staphylococci and enterococci, for which MICs for 90% of isolates were < or = 0.13 micrograms/ml. It was equally active against isolates resistant to beta-lactams, erythromycin, gentamicin, and glycopeptides. It also had activity against Mycobacterium tuberculosis. MDL 62,879 had moderate bactericidal activity against staphylococci.

MeSH Terms

Anti-Bacterial Agents/pharmacology Drug Resistance, Microbial Enterococcus/drug effects Gram-Positive Bacteria/drug effects Gram-Positive Bacterial Infections/microbiology Microbial Sensitivity Tests Peptides/pharmacology Peptides, Cyclic/pharmacology Staphylococcus/drug effects Streptococcus/drug effects Thiazoles/pharmacology

Chemicals

Anti-Bacterial Agents Peptides Peptides, Cyclic Thiazoles GE 2270 A

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Goldstein B P

Lepetit Research Center, Marion Merrell Dow Research Institute, Gerenzano, Varese, Italy.

Berti M

Ripamonti F

Resconi A

Scotti R

Denaro M

References (8)

8 references, click to expand

Vancomycin-resistant bacteria.
Infect Control Hosp Epidemiol. 1992 Apr;13(4):193-4 PMID: 1593098
In vitro activity of MDL 62,879 (GE2270 A) against aerobic gram-positive and anaerobic bacteria.
Antimicrob Agents Chemother. 1993 Apr;37(4):746-9 PMID: 8494370
Inhibition of bacterial protein synthesis by elongation-factor-Tu-binding antibiotics MDL 62,879 and efrotomycin.
Biochem J. 1992 May 1;283 ( Pt 3):649-52 PMID: 1590753
New antibiotic that acts specifically on the GTP-bound form of elongation factor Tu.
EMBO J. 1991 Apr;10(4):779-84 PMID: 2009857
Methicillin-resistant Staphylococcus aureus--a reappraisal.
J Hosp Infect. 1991 Nov;19(3):147-52 PMID: 1685502
Antibiotic GE2270 a: a novel inhibitor of bacterial protein synthesis. I. Isolation and characterization.
J Antibiot (Tokyo). 1991 Jul;44(7):693-701 PMID: 1908853
Bacterial challenges and evolving antibacterial drug strategy.
Postgrad Med J. 1992 Jan;68(795):6-21 PMID: 1561196
Mutations of Bacteria from Virus Sensitivity to Virus Resistance.
Genetics. 1943 Nov;28(6):491-511 PMID: 17247100

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.37.4.741

Published

1993-04-00

Pages

741-5

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC187747

Subset

External Links

PubMed source DOI: 10.1128/AAC.37.4.741 PMC Full Text View journal details

Analysis Services

In vitro antimicrobial activity of a new antibiotic, MDL 62,879 (GE2270 A).

Contact

WeChat Official Account