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题目:: T-Lymphocytes bearing the gamma delta T-cell receptor in cutaneous lesions of Langerhans' cell histiocytosis.
作者:: Alaibac(M),Chu(A C)
状态:: 发布时间1993-06-11 , 更新时间 2006-11-15
期刊:: Med Pediatr Oncol
摘要:: The aim of this study was to investigate the regional importance of gamma delta T cells in cutaneous lesions of Langerhans' cell histiocytosis. Six cases of Langerhans' cell histiocytosis were investigated by immunohistochemical techniques (alkaline phosphatase-antialkaline phosphatase complex and indirect immunoperoxidase). Increase of gamma delta T cells was observed in 3 cases of Langerhans' cell histiocytosis. In these cases up to 30% of CD3+ cells stained with an anti-TCR gamma delta monoclonal antibodies and in two of them gamma delta T cells showed a marked epidermotropism. In the specimens of the remaining three cases gamma delta T cells were found in an overall percentage of 5% of CD3+ cells, but in two cases a significant increase of epidermal gamma delta T cells was observed. The finding of numerous gamma delta T cells in Langerhans' cell histiocytosis is provocative and supports the suggestion of a functional relationship between gamma delta T cells and LCH cells.
语言:: eng
DOI:

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