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题目:: Quantification of resident inflammatory cells in the human nasal mucosa.
作者:: Igarashi(Y),Kaliner(M A),Hausfeld(J N),Irani(A A),Schwartz(L B),White(M V)
状态:: 发布时间1993-06-11 , 更新时间 2006-11-15
期刊:: J Allergy Clin Immunol
摘要:: To define the normal resident inflammatory cell population in the nasal mucosa, surgical specimens of human nasal turbinates were immunohistologically stained for various cell markers.,Freeze-dried paraffin-embedded sections were stained for lymphocyte cell-surface markers, and Carnoy's fixed sections were stained for mast cells and immunoglobulins. The numbers of stained cells were microscopically counted.,T cells (CD3+ cells) were abundant in the lamina propria, and the number of CD4+ cells and CD8+ cells accounted for two thirds and one third of CD3+ cell number, respectively. Cells that stained for the alpha-chain of the interleukin-2 receptor (activated cells, CD25+) were limited and accounted for only 0.6% of CD3+ cell number. B cells (CD22+ cells) and monocytes and macrophages (CD14+ cells) were observed less frequently than T cells. Many immunoglobulin-producing cells were found in close proximity to the submucosal glands, and those cells were predominantly IgA+. Mast cells were widely distributed in the nasal mucosa, and about one third of these cells were stained for IgE molecules. Nonmast cells bearing IgE were rarely observed.,Thus the dominant cell in the nasal mucosa is a CD3+, CD4+, CD25-lymphocyte.
语言:: eng
DOI:

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