Home LiteratureArticle Details
PMID: 846566 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Direct demonstration of beta-globin mRNA in homozygous Ferrara betaO-thalassaemia patients.

Nature ·Vol. 266 ·No. 5599 ·1977-03-17 ·Pages 231-4

Ottolenghi S, Comi P, Giglioni B, Williamson R, Vullo G, Conconi F

Abstract

In cases of betaO-thalassaemia from Ferrara, Italy, the beta-globin gene in transcribed into mRNA but no protein is synthesised. For these cases there is no hybridisation data suggesting a globin gene structural mutation. This again demonstrates the diverse molecular events which may cause this prevalent hereditary disease.

MeSH Terms
Blood Transfusion Bone Marrow/metabolism Bone Marrow Cells Globins/biosynthesis Hemoglobins, Abnormal/biosynthesis Humans Nucleic Acid Hybridization RNA, Messenger/blood Reticulocytes/metabolism Thalassemia/blood
Chemicals
Hemoglobins, Abnormal RNA, Messenger Globins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Ottolenghi S
Comi P
Giglioni B
Williamson R
Vullo G
Conconi F
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/266231a0
Published
1977-03-17
Pages
231-4
Language
English
Region
England
NLM ID
0410462
Subset
IM
External Links
PubMed source DOI: 10.1038/266231a0 View journal details
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