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PMID: 8462680 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Metabolic channelling and control of the flux.

FEBS letters ·Vol. 320 ·No. 1 ·1993-03-29 ·Pages 71-4

Kholodenko BN, Westerhoff HV

Abstract

Metabolic control theory is extended to include channelled metabolism in general. A simple relationship between the flux control by the enzymes and the degree of metabolite channelling is derived. This relationship suggests experiments in which modulation of gene expression allows one to quantify channelling.

MeSH Terms
Enzymes/metabolism Kinetics Metabolism Models, Biological Thermodynamics
Chemicals
Enzymes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kholodenko B N
E.C. Slater Institute, University of Amsterdam, The Netherlands.
Westerhoff H V
Article Info
Journal
FEBS letters
Abbr.
FEBS Lett
ISSN
0014-5793
DOI
10.1016/0014-5793(93)81660-r
Published
1993-03-29
Pages
71-4
Language
English
Region
England
NLM ID
0155157
Subset
IM
External Links
PubMed source DOI: 10.1016/0014-5793(93)81660-r View journal details
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