The role of c-myc in cell growth.

Current opinion in genetics & development ·Vol. 3 ·No. 1 ·1993-02-00 ·Pages 44-9

Evan GI, Littlewood TD

Abstract

Recent experiments have established that the c-myc oncogene encodes a sequence-specific DNA-binding protein that interacts with a specific intracellular partner, Max, and probably manifests its effects through transcriptional modulation. In addition, the range of biological functions attributed to expression of c-myc has grown to include not only transformation and mitogenesis but also cell death.

Related Genes

N-ras bcl-2 bla-1 bmi-1 c-fos c-myc junB pal-1 pim-1 v-abl

MeSH Terms

Animals Apoptosis/genetics Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Basic-Leucine Zipper Transcription Factors Cell Division/genetics Cell Transformation, Neoplastic/genetics,metabolism DNA-Binding Proteins/metabolism Gene Expression Regulation Genes, myc Humans Interphase Mitosis/genetics Proto-Oncogene Proteins c-myc/physiology Transcription Factors/physiology Transcription, Genetic

Chemicals

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Basic-Leucine Zipper Transcription Factors DNA-Binding Proteins MAX protein, human Myc associated factor X Proto-Oncogene Proteins c-myc Transcription Factors

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Evan G I

Biochemistry of the Cell Nucleus Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.

Littlewood T D

Article Info

Journal

Current opinion in genetics & development

Abbr.

Curr Opin Genet Dev

ISSN

0959-437X

DOI

10.1016/s0959-437x(05)80339-9

Published

1993-02-00

Pages

44-9

Language

English

Region

England

NLM ID

9111375

Subset

External Links

PubMed source DOI: 10.1016/s0959-437x(05)80339-9 View journal details

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