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PMID: 8452368 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Abnormal peptidoglycan produced in a methicillin-resistant strain of Staphylococcus aureus grown in the presence of methicillin: functional role for penicillin-binding protein 2A in cell wall synthesis.

Antimicrobial agents and chemotherapy ·Vol. 37 ·No. 2 ·1993-02-00 ·Pages 342-6

de Jonge BL, Tomasz A

Abstract

Upon the addition of methicillin even at relatively low concentrations (5 mug/ml or 0.3% of the MIC) to the medium, methicillin-resistant staphylococci shift to the production of a new peptidoglycan with an abnormal muropeptide composition which may be the synthetic product of penicillin-binding protein 2A.

Related Genes

mec

MeSH Terms

Amino Acid Sequence Bacterial Proteins Carrier Proteins/physiology Cell Wall/drug effects,metabolism,ultrastructure Chromatography, High Pressure Liquid Hexosyltransferases Methicillin/pharmacology Methicillin Resistance/physiology Microscopy, Electron Molecular Sequence Data Muramoylpentapeptide Carboxypeptidase/physiology Penicillin-Binding Proteins Peptidoglycan/analysis,biosynthesis Peptidyl Transferases Staphylococcus aureus/metabolism,ultrastructure Substrate Specificity

Chemicals

Bacterial Proteins Carrier Proteins Penicillin-Binding Proteins Peptidoglycan Peptidyl Transferases Hexosyltransferases Muramoylpentapeptide Carboxypeptidase Methicillin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

de Jonge B L

Rockefeller University, New York, New York 10021.

Tomasz A

References (9)

9 references, click to expand

Effects of growth of methicillin-resistant and -susceptible Staphylococcus aureus in the presence of beta-lactams on peptidoglycan structure and susceptibility to lytic enzymes.
Antimicrob Agents Chemother. 1986 Feb;29(2):250-7 PMID: 2872855
Two distinct transpeptidation reactions during murein synthesis in Escherichia coli.
J Bacteriol. 1987 Jul;169(7):3099-103 PMID: 3298212
Evolution of an inducible penicillin-target protein in methicillin-resistant Staphylococcus aureus by gene fusion.
FEBS Lett. 1987 Aug 31;221(1):167-71 PMID: 3305073
Involvement of multiple genetic determinants in high-level methicillin resistance in Staphylococcus aureus.
J Bacteriol. 1989 Feb;171(2):874-9 PMID: 2536684
THE FINE STRUCTURE OF DIPLOCOCCUS PNEUMONIAE.
J Cell Biol. 1964 Aug;22:453-67 PMID: 14203390
Penicillin-induced changes in the cell wall composition of Staphylococcus aureus before the onset of bacteriolysis.
Arch Microbiol. 1990;154(1):73-81 PMID: 2396890
Cross-linking and O-acetylation of peptidoglycan in Staphylococcus aureus (strains H and MR-1) grown in the presence of sub-growth-inhibitory concentrations of beta-lactam antibiotics.
J Gen Microbiol. 1991 Jul;137(7):1661-6 PMID: 1955858
Peptidoglycan composition of a highly methicillin-resistant Staphylococcus aureus strain. The role of penicillin binding protein 2A.
J Biol Chem. 1992 Jun 5;267(16):11248-54 PMID: 1597460
Binding of beta-lactam antibiotics to penicillin-binding proteins in methicillin-resistant Staphylococcus aureus.
J Infect Dis. 1990 Jun;161(6):1170-6 PMID: 2345297

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.37.2.342

Published

1993-02-00

Pages

342-6

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC187665

Subset

Grants

NIAID NIH HHS · R01 AI 16794 · United States

External Links

PubMed source DOI: 10.1128/AAC.37.2.342 PMC Full Text View journal details

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Abnormal peptidoglycan produced in a methicillin-resistant strain of Staphylococcus aureus grown in the presence of methicillin: functional role for penicillin-binding protein 2A in cell wall synthesis.

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