Nicotinic receptor agonists facilitate retention of avoidance training: participation of dopaminergic mechanisms.

The effect of nicotinic receptor agonists on retention of the inhibitory avoidance (IA) response were investigated in mice. Animals received intraperitoneal drug injections before training, and retention was evaluated 24 h later. Nicotine and cytisine, but not lobeline, significantly increased retention of the IA training. Cotinine, the main metabolite of nicotine, was inactive in the same test. Retention was not affected by the injection of the D1-D2 receptor antagonist cis-flupentixol, but the preadministration of cis-flupentixol significantly blocked the facilitatory effect of nicotine and cytisine on memory. These results demonstrate that the nicotinic receptor agonists nicotine and cytisine facilitate the retention of avoidance responses and suggest that this effect is mediated through central dopaminergic pathways.