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PMID: 843585 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

On the voltage-dependent action of tetrodotoxin.

Biophysical journal ·Vol. 17 ·No. 3 ·1977-03-00 ·Pages 275-9

Cohen IS, Strichartz GR

Abstract

The use of the maximum rate-of-rise of the action potential (Vmax) as a measure of the sodium conductance in excitable membranes is invalid. In the case of membrane action potentials, Vmax depends on the total ionic current across the membrane; drugs or conditions that alter the potassium or leak conductances will also affect Vmax. Likewise, long-term depolarization of the membrane lessens the fraction of total ionic current that passes through the sodium channels by increasing potassium conductance and inactivating the sodium conductance, and thereby reduces the effect of Vmax of drugs that specifically block sodium channels. The resultant artifact, an apparent voltage-dependent potency of such drugs, is theoretically simulated for the effects of tetrodotoxin on the Hodgkin-Huxley squid axon.

MeSH Terms
Action Potentials/drug effects Animals Axons/drug effects,physiology Decapodiformes Mathematics Membrane Potentials/drug effects Tetrodotoxin/pharmacology
Chemicals
Tetrodotoxin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cohen I S
Strichartz G R
References (25)
25 references, click to expand
  1. Effect of procaine on electrical properties of squid axon membrane.
    Am J Physiol. 1959 May;196(5):1071-8 PMID: 13649934
  2. The action of calcium on the electrical properties of squid axons.
    J Physiol. 1957 Jul 11;137(2):218-44 PMID: 13449874
  3. A quantitative description of membrane current and its application to conduction and excitation in nerve.
    J Physiol. 1952 Aug;117(4):500-44 PMID: 12991237
  4. Molecular mechanisms of nerve block by local anesthetics.
    Anesthesiology. 1976 Oct;45(4):421-41 PMID: 9844
  5. Tetrodotoxin-resistant action potentials in newborn rat muscle.
    Nat New Biol. 1973 Jun 6;243(127):191-2 PMID: 4514634
  6. The binding of labelled saxitoxin to the sodium channels in nerve membranes.
    J Physiol. 1973 Dec;235(3):783-804 PMID: 4772409
  7. The receptor for tetrodotoxin and saxitoxin. A structural hypothesis.
    Biophys J. 1975 Jun;15(6):615-9 PMID: 1148362
  8. Studies on tetrodotoxin resistant action potentials in denervated skeletal muscle.
    Acta Physiol Scand. 1971 Nov;83(3):382-8 PMID: 5134176
  9. Charges and potentials at the nerve surface. Divalent ions and pH.
    J Gen Physiol. 1968 Feb;51(2):221-36 PMID: 5641636
  10. Pharmacological modifications of the sodium channels of frog nerve.
    J Gen Physiol. 1968 Feb;51(2):199-219 PMID: 5641635
  11. Differentiation of the actions of tetrodotoxin and saxitoxin.
    Toxicon. 1967 Jul;5(1):25-34 PMID: 6036247
  12. Modification of sodium channel gating in frog myelinated nerve fibres by Centruroides sculpturatus scorpion venom.
    J Physiol. 1975 Jan;244(2):511-34 PMID: 1079869
  13. The influence of pH on equilibrium effects of tetrodotoxin on myelinated nerve fibres of Rana esculenta.
    J Physiol. 1975 Oct;252(1):159-84 PMID: 492
  14. Tetrodotoxin, saxitoxin, and related substances: their applications in neurobiology.
    Int Rev Neurobiol. 1972;15:83-166 PMID: 4347729
  15. Negative surface charge near sodium channels of nerve: divalent ions, monovalent ions, and pH.
    Philos Trans R Soc Lond B Biol Sci. 1975 Jun 10;270(908):301-18 PMID: 238230
  16. Batrachotoxin: chemistry and pharmacology.
    Science. 1971 Jun 4;172(3987):995-1002 PMID: 4324825
  17. Ca spike.
    Adv Biophys. 1973;4:71-102 PMID: 4584559
  18. Ionic blockage of sodium channels in nerve.
    J Gen Physiol. 1973 Jun;61(6):687-708 PMID: 4541078
  19. Evidence that tetrodotoxin and saxitoxin act at a metal cation binding site in the sodium channels of nerve membrane.
    Proc Natl Acad Sci U S A. 1974 Oct;71(10):3936-40 PMID: 4530274
  20. Increase in sodium permeability of squid axon membranes by -dihydrograyanotoxin II.
    J Pharmacol Exp Ther. 1973 Feb;184(2):299-307 PMID: 4688172
  21. Resistance to tetrodotoxin and saxitoxin in nerves of bivalve molluscs. A possible correlation with paralytic shellfish poisoning.
    Toxicon. 1972 May;10(3):273-8 PMID: 5072092
  22. The effect of veratridine on excitable membranes of nerve and muscle.
    Ergeb Physiol. 1969;61:18-71 PMID: 4903416
  23. Ionic channels in nerve membranes.
    Prog Biophys Mol Biol. 1970;21:1-32 PMID: 4913288
  24. Structure and activity of tetrodotoxin derivaties.
    Jpn J Pharmacol. 1967 Jun;17(2):267-78 PMID: 5299985
  25. Voltage-dependent action of tetrodotoxin in mammalian cardiac muscle.
    Nature. 1976 Sep 23;263(5575):344-5 PMID: 958493
Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(77)85656-7
Published
1977-03-00
Pages
275-9
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1473237
Subset
IM
External Links
PubMed source DOI: 10.1016/S0006-3495(77)85656-7 PMC Full Text View journal details
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