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PMID: 8435473 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The role of cell adhesion molecules in cancer invasion and metastasis.

Breast cancer research and treatment ·Vol. 24 ·No. 3 ·1993-00-00 ·Pages 175-84

Behrens J

Abstract

Invasion and metastasis of tumor cells is the primary cause for the fatal outcome of cancer diseases. A striking feature of metastatic cells is the considerable flexibility in their adhesive interactions with other cells or components of the extracellular matrix. This review will describe the involvement of specific cell adhesion receptors, extracellular matrix molecules, and cell dissociating cytokines in the metastatic cascade. We will particularly focus on disturbance of intercellular adhesion as a prerequisite for the release of invasive cells from carcinomas. We suggest that cell dissociation in these tumors is accomplished by loss of function or expression of the epithelial cell adhesion molecule E-cadherin, and through the activity of cell motility factors, like scatter factor.

MeSH Terms
Animals Base Sequence Breast Neoplasms/metabolism,pathology Cadherins/chemistry,genetics,physiology Carcinoma/metabolism,pathology Cell Adhesion/physiology Extracellular Matrix/pathology Female Gene Expression Regulation, Neoplastic Hepatocyte Growth Factor/chemistry,physiology Humans Molecular Sequence Data Neoplasm Invasiveness/physiopathology Neoplasm Metastasis/physiopathology
Chemicals
Cadherins Hepatocyte Growth Factor
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Behrens J
University of Essen Medical School, Germany.
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Article Info
Journal
Breast cancer research and treatment
Abbr.
Breast Cancer Res Treat
ISSN
0167-6806
DOI
10.1007/BF01833258
Published
1993-00-00
Pages
175-84
Language
English
Region
Netherlands
NLM ID
8111104
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01833258 View journal details
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