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PMID: 8423103 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The gamma-hemolysin locus of Staphylococcus aureus comprises three linked genes, two of which are identical to the genes for the F and S components of leukocidin.

Infection and immunity ·Vol. 61 ·No. 2 ·1993-02-00 ·Pages 768-71

Cooney J, Kienle Z, Foster TJ, O'Toole PW

Abstract

The Staphylococcus aureus gamma-hemolysin comprises two polypeptides, whereas the gamma-hemolysin locus (hlg) contains three open reading frames. The hlgA and hlgB genes encode the gamma 1 and gamma 2 components, respectively. The HlgB protein (gamma 2) has 27% residue identity with S. aureus alpha-toxin. Surprisingly, hlgB and hlgC are 98.5 and 99.1% identical to the lukF and lukS genes, respectively, encoding the F and S components of the Panton-Valentine leukocidin.

Related Genes
hlgA hlgB hlgC
MeSH Terms
Amino Acid Sequence Bacterial Toxins/genetics Base Sequence Chromosome Mapping Genes, Bacterial Hemolysin Proteins/genetics Leukocidins/genetics Molecular Sequence Data Staphylococcus aureus/genetics
Chemicals
Bacterial Toxins Hemolysin Proteins Leukocidins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Cooney J
Department of Medical and Physiological Chemistry, University of Lund, Sweden.
Kienle Z
Foster T J
O'Toole P W
References (10)
10 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.61.2.768-771.1993
Published
1993-02-00
Pages
768-71
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC302792
Subset
IM
Databases
GENBANK
L01055
External Links
PubMed source DOI: 10.1128/iai.61.2.768-771.1993 PMC Full Text View journal details
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